Clinical trials

Participating in a clinical trial or taking part in a research study can be a very rewarding way to get involved in helping to ensure all patients have access to safe and effective treatments. Trials are run on a stepped basis, overseen by regulators like the FDA. Each phase expands the numbers of participants and if successful brings the proposed treatment to approval. Phase I trial – safety. Phase II trial – safety and dose. Phase III trial – safety and efficacy. Phase IV trials – post approval surveillance.

Now recruiting PBC patients in Canada

There are many clinical trials taking place in Canada (list updated August 2022).  If you are interested in participating in any of these trials, ask your specialist to find out if you would benefit from and/or qualify for any of these clinical trials.

  • SELADELPAR (CymaBay) – Phase 3 trial enrolling:  Toronto, Ontario (2 sites), London Ontario, Ottawa Ontario. Learn more about what’s involved and how to enroll.  Also, read more about the study and worldwide locations on clinicaltrials.gov.
  • ELAFIBRANOR (Genfit) – Phase 3 trial currently enrolling: Vancouver, Calgary, Winnipeg & Montreal. Learn more about what’s involved and how to enroll.  Also read more about the study and worldwide locations on  clinicaltrials.gov. 
  • LINERIXIBAT (GSK) – Phase 3 long term study currently enrolling: Toronto and Ottawa, Ontario. Learn more about what’s involved and how to enroll.  Also read more about the study and worldwide locations on clinicaltrials.gov. 
  • SETANAXIB (Calliditas) – Phase 2b/ trial enrolling sites in Canada: In Ontario:  Toronto, North York, London, Brampton & North Bay.  In Alberta:  Calgary.  Learn more about what’s involved and how to enroll.  Also read more about the study and worldwide locations on clinicaltrials.gov. 

Other active/upcoming PBC clinical trials

  • OCALIVA (Intercept)  – Phase 4 COBALT long term study, currently enrolling: Toronto, London, Calgary, Edmonton, Winnipeg, Montreal
  • EP547 (Escient) –  Phase 2 PACIFIC study now enrolling.  Learn more about what’s involved and how to enroll – also read more about the study and worldwide location on clinicaltrials.gov – no active sites in Canada
  • VOLIXIBAT (Mirum) – Phase 2 trial now enrolling – no active sites in Canada
  • SAROGLITAZER MAGNESIUM (Zydus) – Phase 2b/3 trial  now enrolling in Indianapolis – no active sites in Canada

Terminated PBC clinical trials

  • EDP-305 (Enanta) – terminated
  • ABATACEPT (Bristol-Myers Squibb) – terminated
  • CILOFEXOR (Gilead) – terminated
  • ETRASIMOD (Arena) – terminated
  • TROPIFEXOR (Novartis) – terminated

To see ALL PBC CLINICAL TRIALS, check:

www.clinicaltrials.gov
or use the CLINICAL TRIAL search tool below: