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Clinical trials

Participating in a clinical trial or taking part in a research study can be a very rewarding way to get involved in helping to ensure all patients have access to safe and effective treatments. Trials are run on a stepped basis, overseen by regulators like the FDA. Each phase expands the numbers of participants and if successful brings the proposed treatment to approval. Phase I trial – safety. Phase II trial – safety and dose. Phase III trial – safety and efficacy. Phase IV trials – post approval surveillance.

Active – Now Recruiting

There are many clinical trials taking place in Canada (list updated July 2026).  If you are interested in participating in any of these trials, ask your specialist to find out if you would benefit from and/or qualify for any of these clinical trials.

  • SELADELPAR (Gilead)
    • Long-Term (est. 3 year duration), Phase III enrolling now (AFFIRM Study)
    • Locations: Calgary, Edmonton, Montreal, Ottawa, Quebec City, Toronto, Vancouver /  Learn More
  • ELAFIBRANOR (Ipsen)
    • Long-Term (est. 3.5 year duration), Phase III enrolling now (ELFIDENCE Study)
    • Locations: Edmonton, Toronto / Learn More
  • ELAFIBRANOR (Ipsen)
    • Now enrolling PBC patients who are starting or currently taking ELAFIBRANOR
    • Observational, Long-Term (est. 5 year duration) (ELFINITY Study)
    • Locations: Calgary, London, Ottawa, Vancouver, Montreal / Learn More
  • GOLEXANOLONE (Umecrine cognition AB) – FOR PBC FATIGUE & COGNITION
    • NO SITES IN CANADA
    • Now recruiting PBC patients at sites outside of Canada  / Learn More

Active – Not Recruiting

  • VOLIXIBAT (Mirum)
    • Study has just stopped recruiting new participants 
    • Phase II (VANTAGE Study)
    • Learn More
  • SELADELPAR (Gilead)
    • For PBC patients who have already participated in a previous SELADELPAR study
    • Open-Label, Long-term (ASSURE Study)
    • Learn More
  • ELAFIBRANOR (Ipsen)
  • LINERIXIBAT (Alphasigma)
  • PEMAFIBRATE (Kowa)
  • SAROGLITAZAR MAGNESIUM (Zydus)

Terminated

  • OCA + BZF (Aphasigma) – terminated 
  • CNP-104 (COUR) – terminated
  • SETANAXIB (Calliditas) – terminated
  • EP547 (Escient) – terminated
  • OCALIVA (Intercept) – terminated
  • EDP-305 (Enanta) – terminated
  • ABATACEPT (Bristol-Myers Squibb) – terminated
  • CILOFEXOR (Gilead) – terminated
  • ETRASIMOD (Arena) – terminated
  • TROPIFEXOR (Novartis) – terminated 

To see ALL PBC CLINICAL TRIALS, check: www.clinicaltrials.gov
or use the CLINICAL TRIAL search tool below: