PBC Research

Cholestasis-Associated Pruritus and Its Pruritogens

Jacqueline A. G. M. Langedijk, Ulrich H. Beuers and Ronald P. J. Oude Elferink* published March 9, 2021, frontiers in Medicine. “Cholestasis is the term for diminished or impaired bile flow generated by hepatocytes and cholangiocytes. The cause of cholestasis can be intra- or extrahepatic, and can be genetic or

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Prognostic Factors for Clinical Outcomes in Patients with PBC

This thesis, written by Dr. Carla Fiorella Murillo Perez was published January 2021.  The study uses a large and globally representative cohort of patients with long-term follow-up to study various prognostic factors in primary biliary cholangitis (PBC). Prognostic factors evaluated include calendar time, geographical region, age, gender, risk scores in

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EL-FIT program helps keep liver patients fit!

El-Fit offers a custom exercise program, tailored to meet the individual needs of liver patients.  Using a friendly APP, the program allows patients to set goals and track progress, as well as share results with other participants in the program.  Read more about the study from the University of Pittsburgh.

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PBC Patient Guidelines

This year the PBC Network created a 36 page booklet “PBC – Living With Your Diagnosis” . The Canadian PBC Society participated in the final review of this comprehensive patient guideline and is now a proud member of the PBC Network.  Read the guidelines here.

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Testing Mirtazapine on Mice

University of Calgary PBC researchers tested the anti-depressant mirtazapine on mice and found promising results. Their report concluded that mirtazapine may represent a novel therapeutic approach to autoimmune liver disease.  We look forward to see the next steps in this research.  Read the research findings here.

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Results of our Patient Survey

Read the results of our patient survey which was initiated in 2015, with more than 250 PBC patients reporting how PBC affects their daily lives.  We worked with a research team from the University of Alberta in Edmonton to look at the data and this report summarizes our findings.  Read

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How do you Diagnose PBC?

The Toronto Centre for Liver Disease recently published a graphic that explains how specialists diagnose PBC.  Thanks to Dr. Gideon Hirschfield and Marwa Ismail for this concise explanation.Download the graphic here.

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Your Liver & Cirrhosis

Thanks to the Gastrointestinal Society in association with the Canadian Society of Intestinal Research for this excellent graphic describing Liver Cirrhosis and providing you with a tool to discuss your Liver with your specialist.  Note:  There is a spot on the graphic to record your Liver Disease, Liver Stiffness and

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